Interleukin 1 inhibits contraction of vascular smooth muscle.
نویسندگان
چکیده
منابع مشابه
Oxygen and vascular smooth muscle contraction.
DETAR, REED, AND DAVID F. BOHR. Oxygen and vascular smooth muscle contraction. Am. J. Physiol. 214(Z): 241-244. 1968.-Oxygen tension is an important determinant of the contractile tension developed by isolated helical strips of rabbit aorta. A decrease in PO:! below 100 mm Hg causes the contractile response to epinephrine (l-3 pg/liter) to diminish linearly to near zero levels at < 1 mm Hg. If ...
متن کاملVascular smooth muscle contraction in hypertension
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to increased vascular contraction and arterial remo...
متن کاملCalcium and vascular smooth muscle contraction.
Radioactive calcium flux in rabbit aorta was studied to evaluate factors regulating the movement of calcium into and out of the cell. Calcium content was estimated both from (1) the amount of Ca present in the tissue and the specific activity of Ca in the bathing medium, and (2) determination of chemical calcium by atomic absorption spectrophotometry. Calcium efflux was followed by washing aort...
متن کاملTanshinone IIA inhibits AGEs-induced proliferation and migration of cultured vascular smooth muscle cells by suppressing ERK1/2 MAPK signaling
Objective(s): Vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetic vascular disease. Our current study sought to explore the effects of tanshinone IIA on the proliferation and migration of VSMCs induced by advanced glycation end products (AGEs). Materials and Methods: In this study, we examined the effects of tanshinone IIA by cell proliferation assay and cell mi...
متن کاملHuman interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells
The recognition that cells of the vascular wall can secrete cytokines such as IL-1 suggests new mechanisms for initiating or sustaining inflammatory responses in blood vessels. We report that purified human monocyte-derived IL-1 or recombinant human IL-1 (rIL-1 beta and rIL-1 alpha) induce cultured human smooth muscle cells derived from veins or arteries to synthesize IL-1 beta mRNA and produce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1989
ISSN: 0021-9738
DOI: 10.1172/jci113879